![]() Ferroptosis is associated with the accumulation of iron, ROS, lipid peroxidation, and insufficient capacity to eliminate lipid peroxidation. Initially, ferroptosis has been discovered as a novel iron-dependent form of non-apoptotic regulated cell death. Ferroptosis is a new type of cell death discovered in the past decade. In addition, we discuss the contribution of autophagy to ferroptosis and elucidate the role of autophagy as a ferroptosis enhancer during ROS-dependent ferroptosis.Ĭell death is critical in the development of multiple human diseases and is closely linked to biological growth. In this review, we summarize the current knowledge regarding the regulatory mechanisms underlying ferroptosis, including iron and lipid metabolism, and its association with the autophagy pathway. Understanding the roles and pathophysiological processes of autophagy during ferroptosis may provide effective strategies for the treatment of ferroptosis-related diseases. However, accumulating evidence has revealed a link between autophagy and ferroptosis at the molecular level and has suggested that autophagy is involved in regulating the accumulation of iron-dependent lipid peroxidation and ROS during ferroptosis. Ferroptosis is defined as a reactive oxygen species (ROS)-dependent cell death related to iron accumulation and lipid peroxidation, which is different from apoptosis, necrosis, autophagy, and other forms of cell death. Ferroptosis, a programmed cell death, has been identified and associated with cancer and various other diseases. ![]()
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